Contents

CBD 101: What Does CBD Stand For

Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. View abstract.

CANNABIDIOL (CBD) – Uses, Side Effects, and More

Cannabidiol (CBD) is a chemical in the Cannabis sativa plant, also known as cannabis or hemp. One specific form of CBD is approved as a drug in the U.S. for seizures.

Over 80 chemicals, known as cannabinoids, have been found in the Cannabis sativa plant. Delta-9-tetrahydrocannabinol (THC) is the most famous ingredient in cannabis. But CBD is obtained from hemp, a form of the Cannabis sativa plant that only contains small amounts of THC. CBD seems to have effects on some chemicals in the brain, but these are different than the effects of THC.

A prescription form of CBD is used for seizure disorder (epilepsy). CBD is also used for anxiety, pain, a muscle disorder called dystonia, Parkinson disease, Crohn disease, and many other conditions, but there is no good scientific evidence to support these uses.

Laws passed in 2018 made it legal to sell hemp and hemp products in the US. But that doesn’t mean that all CBD products made from hemp are legal. Since CBD is an approved prescription drug, it can’t be legally included in foods or dietary supplements. CBD can only be included in “cosmetic” products. But there are still CBD products on the market that are labeled as dietary supplements. The amount of CBD contained in these products is not always the same as what is stated on the label.

Uses and Effectiveness ?

Likely Effective for

  • Seizure disorder (epilepsy). A specific prescription product (Epidiolex, GW Pharmaceuticals) is approved by the US FDA to treat seizures caused by Dravet syndrome, Lennox-Gastaut syndrome, or tuberous sclerosis complex. It is unclear if other forms of CBD are helpful for seizure. For now, stick with the prescription product.

Possibly Effective for

  • Multiple sclerosis (MS). A prescription-only nasal spray product (Sativex, GW Pharmaceuticals) containing both 9-delta-tetrahydrocannabinol (THC) and cannabidiol has been shown to be effective for improving pain, muscle-tightness, and urination frequency in people with MS. This product is used in over 25 countries outside of the United States. But there is inconsistent evidence on the effectiveness of cannabidiol for symptoms of multiple sclerosis when it is used alone. Some early research suggests that using a cannabidiol spray under the tongue might improve pain and muscle tightness, but not muscle spasms, tiredness, bladder control, mobility, or well-being and quality of life in patients with MS.

Side Effects

When taken by mouth: CBD is possibly safe to take in appropriate doses. Doses of up to 200 mg daily have been used safely for up to 13 weeks. With the guidance of a healthcare provider, a specific prescription CBD product (Epidiolex) has been used at higher doses and for longer durations.

CBD can cause some side effects, such as dry mouth, low blood pressure, light headedness, and drowsiness. Signs of liver injury have also been reported with high doses of the prescription form of CBD, called Epidiolex.

When applied to the skin: There isn’t enough reliable information to know if CBD is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: CBD is possibly safe to take in appropriate doses. Doses of up to 200 mg daily have been used safely for up to 13 weeks. With the guidance of a healthcare provider, a specific prescription CBD product (Epidiolex) has been used at higher doses and for longer durations.

CBD can cause some side effects, such as dry mouth, low blood pressure, light headedness, and drowsiness. Signs of liver injury have also been reported with high doses of the prescription form of CBD, called Epidiolex.

When applied to the skin: There isn’t enough reliable information to know if CBD is safe or what the side effects might be. Pregnancy and breast-feeding: It may be unsafe to take CBD if you are pregnant or breast feeding. CBD products can be contaminated with other ingredients that may be harmful to the fetus or infant. Stay on the safe side and avoid use.

Children: It is possibly safe for children to take a specific prescription CBD product (Epidiolex) by mouth in doses up to 25 mg/kg daily. This product is approved for use in children with certain conditions who are at least 1 year old. It isn’t clear if other CBD products are safe in children.

A group of eye disorders that can lead to vision loss (glaucoma): Some early research suggests that taking CBD might increase the pressure in the eye in some people with glaucoma.

Liver disease: People with liver disease may need to use lower doses of CBD.

Parkinson disease: Some early research suggests that taking high doses of CBD might make muscle movement and tremors worse in some people with Parkinson disease.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 1B1 (CYP1B1) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2A6 (CYP2A6) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with CANNABIDIOL (CBD)

Sedative medications (CNS depressants) interacts with CANNABIDIOL (CBD)

Clobazam (Onfi) interacts with CANNABIDIOL (CBD)

Eslicarbazepine (Aptiom) interacts with CANNABIDIOL (CBD)

Rufinamide (Banzel) interacts with CANNABIDIOL (CBD)

Topiramate (Topamax) interacts with CANNABIDIOL (CBD)

Valproate interacts with CANNABIDIOL (CBD)

Zonisamide interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2C8 (CYP2C8) substrates) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Glucuronidated drugs) interacts with CANNABIDIOL (CBD)

Medications that increase the breakdown of other medications by the liver (Cytochrome P450 2C19 (CYP2C19) inducers) interacts with CANNABIDIOL (CBD)

Medications that increase breakdown of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers) interacts with CANNABIDIOL (CBD)

Medications that decrease the breakdown of other medications by the liver (Cytochrome P450 2C19 (CYP2C19) inhibitors) interacts with CANNABIDIOL (CBD)

Medications that decrease the breakdown of other medications in the liver (Cytochrome P450 3A4 (CYP3A4) inhibitors) interacts with CANNABIDIOL (CBD)

Brivaracetam (Briviact) interacts with CANNABIDIOL (CBD)

Everolimus (Zostress) interacts with CANNABIDIOL (CBD)

Tacrolimus (Prograf) interacts with CANNABIDIOL (CBD)

Methadone (Dolophine) interacts with CANNABIDIOL (CBD)

Carbamazepine (Tegretol) interacts with CANNABIDIOL (CBD)

Sirolimus (Rapamune) interacts with CANNABIDIOL (CBD)

Stiripentol (Diacomit) interacts with CANNABIDIOL (CBD)

Lithium interacts with CANNABIDIOL (CBD)

Warfarin interacts with CANNABIDIOL (CBD)

Tamoxifen (Nolvadex) interacts with CANNABIDIOL (CBD)

Caffeine interacts with CANNABIDIOL (CBD)

Citalopram (Celexa) interacts with CANNABIDIOL (CBD)

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with CANNABIDIOL (CBD)

Fluoxetine (Prozac) interacts with CANNABIDIOL (CBD)

Dosing

CBD has most often been used by adults in doses of 200 mg or less per day. Speak with a healthcare provider to find out what dose might be best for a specific condition.

For information on using prescription CBD, a product called Epidiolex, speak with a healthcare provider.

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Collin, C., Ehler, E., Waberzinek, G., Alsindi, Z., Davies, P., Powell, K., Notcutt, W., O’Leary, C., Ratcliffe, S., Novakova, I., Zapletalova, O., Pikova, J., and Ambler, Z. A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis. Neurol.Res. 2010;32(5):451-459. View abstract.

Consroe, P., Kennedy, K., and Schram, K. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacol Biochem.Behav. 1991;40(3):517-522. View abstract.

Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K., and Schram, K. Controlled clinical trial of cannabidiol in Huntington’s disease. Pharmacol Biochem.Behav. 1991;40(3):701-708. View abstract.

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Valvassori SS, Elias G, de Souza B, et al. Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychopharmacol 2011;25(2):274-80. View abstract.

van de Donk T, Niesters M, Kowal MA, Olofsen E, Dahan A, van Velzen M. An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. Pain. 2019 Apr;160(4):860-869. View abstract.

van Orten-Luiten AB, de Roos NM, Majait S, Witteman BJM, Witkamp RF. Effects of Cannabidiol Chewing Gum on Perceived Pain and Well-Being of Irritable Bowel Syndrome Patients: A Placebo-Controlled Crossover Exploratory Intervention Study with Symptom-Driven Dosing. Cannabis Cannabinoid Res. 2021. View abstract.

Vela J, Dreyer L, Petersen KK, Lars AN, Duch KS, Kristensen S. Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind placebo-controlled trial. Pain 2021. View abstract.

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CBD 101: What Does CBD Stand For?

CBD Stands for Cannabidiol | CBD Origin

If you’re learning about CBD for the first time, there are probably a ton of questions going through your head. You’ve already determined that the term “CBD” is clearly an acronym, and naturally, the next question that comes to mind is “So, what does CBD stand for?”

A Google search and a few clicks later, and here you are reading this article.

First off, welcome to CBD Origin, we’re so happy to have you. CBD Origin is the leading online publication for CBD knowledge and we’ve made it our mission to provide our readers with all the information and resources they need to fully understand what CBD is and how it can be used in their lives.

Naturally, answering the first question “What does CBD stand for?” is right up our alley.

What Does CBD Stand For?

First off, the three letters “C”, “B”, “D” do not represent an abbreviated form of any three terms, so CBD is technically not an acronym.

“CBD” is the abbreviation for the specific cannabis-derived compound, Cannabidiol.

Occasionally, you will see people misuse the term CBD to refer more generally to cannabinoids, which would include not only Cannabidiol, but other cannabinoids like Delta-9 THC, cannabigerol, Delta-8, etc. That is not the correct definition though, and CBDs is not a plural for cannabinoids in general.

What is Cannabidiol?

Cannabidiol (CBD) is one of the many active compounds that are naturally produced in cannabis known as cannabinoids.

While there is still much to learn about these unique compounds, researchers have confirmed that cannabinoids are the source of the cannabis plant’s various medicinal and recreational properties.

Unlike some of the other cannabinoids, most notably Tetrahyrdacannbinol (THC), CBD is a non-intoxicating compound, which means that it will not induce the mind-altering effects associated with “being high.”

Essentially, CBD can deliver the natural, therapeutic properties of the cannabis plant, without the negative side effects of traditional cannabis use.

How Does CBD Work?

While it was initially believed that cannabinoids were only found in cannabis, in the middle of the 20th century, researchers discovered that cannabinoids were produced in the body of most mammals as part of the Endocannabinoid system (ECS).

The ECS is comprised of millions of endocannabinoid receptors, which are classified into two groups: CB1 receptors and CB2 receptors.

The ECS is spread throughout the body in core health systems including the digestive system, central nervous system, cardiovascular system, and immune system. By utilizing the CB1 and CB2 receptors to relay neurological signals across the body, the ECS acts as a biological communication system that helps to moderate and maintain important functions throughout the body.

Discover the Wonders of CBD

What Does CBD Stand for - Cannabidiol | CBD Origin

Now that we’ve discussed What CBD stands for and shared some general information about CBD, your journey into the amazing world of CBD has just begun.

While there is still so much to learn about this amazing cannabinoid, what we have discovered thus far is absolutely amazing. We are very excited for you and are honored to help guide you through your journey to learn all about CBD and the many ways it can be used to improve your life.

Explore the wide selection of articles, guides, and resources available on our website to expand your knowledge of CBD, what it means to use CBD or other cannabinoids for health reasons, how to pick out and use CBD products, and other non-medical questions you may have about this amazing cannabinoid. As always, please feel free to reach out to our team with any questions you have about CBD.

We created CBD Origin with a goal to provide everyone with a credible resource for everything to know about CBD. We are proud supporters of CBD and the wonders that it promotes, and want to help the world learn about it! Please continue to visit our blog to find new and exciting articles about CBD, and always feel free to engage in our community!

To kick off your journey, here are some quick links to help you navigate throughout our CBD Origin website:

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